Calcium Dobesilate Capsule is a medicine that is used for the treatment of Varicose Veins, Diabetic Retinopathy, Platelet Hyper Aggregation and other conditions.Calcium Dobesilate Capsule contains Calcium Dobesilate as an active ingredient.Detailed information related to Calcium Dobesilate Capsule’s uses, composition, dosage, side effects and reviews is listed below.

Calcium Dobesilate Capsule Uses
Calcium Dobesilate Capsule is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Calcium dobesilate has a comprehensive mode of action. It increases endothelial nitric oxide levels by enhancing the activity of nitric-oxide synthase, decreasing capillary hyper-permeability. Calcium dobesilate shows anti-platelet and fibrinolytic activities by inhibiting platelet activation factor (PAF) and enhancing the release of tissue plasminogen activator (tPA), thereby improving the local blood flow to tissues, otherwise inhibited due to thrombosis. Calcium dobesilate also inhibits the two pathophysiological reactions in diabetes viz polyol pathway and glycation of proteins due to its inhibitory effects on aldose reductase.

Calcium dobesilate acts on the endothelial layer and basement membrane of the capillaries. It reduces histamine and bradykinin – induced hyperpermeability. It increases red blood cell membrane flexibility and reduces capillary fragility. Calcium dobesilate can reduce the platelet aggregation stimulated by collagen and thrombin, but not by arachidonic acid.

Glucose inhibits the formation of both type I and type II collagen formation. Calcium dobesilate does not affect type I inhibition by glucose but accelerates type II collagen fibrillogenesis, a major structural component of the arterial wall. Calcium dobesilate has angioprotective action by reducing the permeability and fragility of microvessels, which should restrict fluid extravasation into the cardiac interstitium. Its antiplatelet effect should counteract thrombosis and its reduction of plasma viscosity should prevent stasis.
Calcium dobesilate is a vasoactive drug with presumed effects on endothelial integrity, capillary permeability, and blood viscosity. It is often recommended for venous disorders, but it is also prescribed for diabetic retinopathy and other microvascular disorders

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